Vyvanse 30mg, 50mg

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As a central systema nervosum stimulant, lisdexamfetamine is employed as an adjunct within the treatment
of attention deficit hyperactivity disorder (ADHD). As a prodrug, lisdexamfetamine was
specifically designed as an abuse-resistant product. After oral administration and absorption,
enzyme hydrolysis following contact with red blood cells will break lisdexamfetamine into Llysine,
a present essential aminoalkanoic acid and active d-amphetamine which is
responsible for the drug’s pharmacological activity.

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 Vyvanse 30mg, 50mg

Lisdexamfetamine is an amide ester conjugate. consisting of the aminoalkanoic acid Llysine covalently sure to the amino of d-amphetamine. vyvanse

Chemical properties

Lisdexamfetamine dimesylate has low lipophilicity (logP-1.76) and high aqueous solubility within a biologically relevant pH range of 1-8. Therefore, It should be stored at 25°C (77°F) with excursions permitted to 15-30°C (59-86°F).
As such, Lisdexamfetamine should be dispensed during a tight, light-resistant container.

General pharmacology of Vyvanse
Lisdexamfetamine may be a prodrug and an inactive molecule until ingestion. After oral administration, enzyme hydrolysis following contact with red blood cells will break lisdexamfetamine into L-lysine, a present essential aminoalkanoic acid and active damphetamine which is liable for the drug’s activity. However, Gastrointestinal pH doesn’t alter this conversion and thus the attachment of the L-lysine slows down the relative amount of d-amphetamine available to the blood stream and therefore the CNS.

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Routes of administration and dosage
Capsule, Oral: 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg.

Pharmacokinetics
Lisdexamfetamine PO is rapidly absorbed via the alimentary canal in animals. It attains a maximum plasma concentration -0.25-3 h. Studies in vitro suggest lisdexamfetamine may be a substrate for the peptide transport protein PEPT1 and perhaps also PEPT2.

Adverse reactions of vyvanse in humans
To begin with, When tested in subjects with a history of stimulant abuse, doses of 50-150 mg oral lisdexamfetamine dose-ependently. Equally, increased systolic and diastolic vital sign , and pulse compared to placebo and therefore the 150 mg dose of lisdexamfetamine produced higher changes than 40 mg d-amphetamine.

Above all, the foremost common adverse effects for lisdexamfetamine are insomnia (13% to 27%), decreased appetite (children and adolescents 34% to 39%; adults 27%), xerostomia (adults 26%; children and adolescents 4% to 5%), and abdominal pain (children 12%). On the opposite hand, adverse effects include increased vital sign (adults 3%), increased pulse . for instance , (adults 2%), irritability (children 10%), anxiety (adults 6%), dizziness (children 5%), akathisia (adults 4%), agitation (adults 3%), emotional lability (children 3%), restlessness (adults 3%), drowsiness (children 2%), tics (children 2%), hyperhidrosis (adults 3%), rash (children 3%).

Dependence potential of vyvanse
To clarify, No studies found on tolerance, sensitization, or dependence to lisdexamfetamine. However, abrupt discontinuation following high doses or for prolonged periods may end in symptoms of withdrawal

Current and past national controls
Not control in some states but controlled in some parts of Europe and Asia

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Qtty

30, 60, 90, 120, 180

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